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Buprenorphine Overdose After Naltrexone Treatment

February 14, 2017 by admin 7 Comments

Naltrexone induces mu-receptor hypersensitivity.  Buprenorphine’s protective ‘ceiling effect’ may not prevent overdose in patients with this ‘reverse tolerance’. A new patient described his recent history of respiratory failure several days into buprenorphine treatment.  He was told by his doctors that he experienced an allergic reaction to Suboxone. The rarity of buprenorphine or naloxone allergy led … [Read more…]

Posted in: Buprenorphine, Induction, pharmacology, receptor actions, side effects, Suboxone, tolerance Tagged: buprenorphine induction, buprenorphine overdose, naltrexone treatment, Suboxone after vivitrol, Suboxone allergy

Benzos and Buprenorphine

January 27, 2017 by admin 6 Comments

The high safety of buprenorphine, except when combined with a benzodiazepine, has been twisted in comments about the drug (and in the minds of regulators) to buprenorphine being uniquely dangerous when combined with benzodiazepines, which is not true. I’ve heard more and more from insurers, regulators, and well-meaning agencies about the dangers of combining buprenorphine … [Read more…]

Posted in: Benzos, Buprenorphine, pharmacology, risks, Suboxone, tolerance Tagged: buprenorphine and benzodiazepines, suboxone overdose, xanax and suboxone

Does Suboxone Stop Working Over Time?

December 11, 2014 by admin Leave a Comment

First Posted 12/31/2013 Buprenorphine is relatively unique among opioids in having a ‘ceiling’ to mu opioid effects.  There are other known molecules that act as partial agonists at mu opioid receptors, but buprenorphine is the most useful, at this point, because of other traits of the molecule– such as having few side effects from actions … [Read more…]

Posted in: receptor actions, Suboxone, tolerance, treatment Tagged: buprenorphine long term, how long does suboxone work, long term suboxone, suboxone tolerance

A New Way to Stop Suboxone?

November 23, 2014 by admin Leave a Comment

Originally Posted 10/27/2013 I usually have my wife/business partner review my posts and provide her opinion whether my arguments are sound.  For the record, she tells me that this post is technical and boring.  I disagree, but we aren’t planning to separate over the issue.  A valid criticism, I think, is that I’m doing a … [Read more…]

Posted in: Buprenorphine, Drug Testing, Mood, Pharma, tolerance Tagged: alks 33, opioid tolerance, samidorphan for depression, stopping suboxone, Suboxone withdrawal

Withdrawal from Suboxone or Buprenorphine

September 23, 2012 by admin 1 Comment

I received a question from a reader about withdrawal symptoms from stopping buprenorphine. My answer has relevance to opioid withdrawal in general, and to a common misconception about the duration of withdrawal symptoms. The message: Basically I quit Suboxone about 18 days ago. When I decided to quit I was taking about 8 to 12mgs per day. I … [Read more…]

Posted in: Addiction, Buprenorphine, Clean Enough, pharmacology, receptor actions, Suboxone, tolerance, Withdrawal Tagged: how long does suboxone withdrawal last, suboxone half life, Suboxone taper, Suboxone withdrawal

A Save with Suboxone?

September 21, 2012 by admin Leave a Comment

I’d like to share a recent email exchange with a reader. The post is long, but there are several interesting aspects to the discussion. I’ve removed the conversational parts, as well as the identifying information. The initial message: I was an intravenous heroin user for three years. After treatment I was able to stay clean … [Read more…]

Posted in: 12 steps, Addiction, Buprenorphine, Clean Enough, pharmacology, receptor actions, recovery, Suboxone, tolerance Tagged: inject buprenorphine, inject Suboxone, overdose, precipitated withdrawal, Suboxone reverse overdose

Questions, Excuses, Krokodil

September 5, 2012 by admin 1 Comment

I’ve been in more of a chatty mood lately, as regular readers have likely noticed.  I find it interesting that weeks will pass when I have little or nothing to say… and at other times, I have all sorts of random thoughts to discuss. Excuses first– I’ve been tinkering with ads for the past few … [Read more…]

Posted in: Addiction, Buprenorphine, Drug Testing, Legal, Suboxone, Suboxone Forum, tolerance Tagged: drug testing and Suboxone, impaired by Suboxone, krokodil effects, Mayo Clinic Suboxone study, Suboxone and healthcare workers, workplace drug testing

Post-op Pain on Suboxone

August 8, 2012 by admin 2 Comments

I often receive emails from patients on buprenorphine (or Suboxone) who are preparing for surgery or other painful medical procedures. Ideally in such cases, the surgeon would have a discussion with the person prescribing buprenorphine, in order to coordinate the plan for treating postoperative pain. In practice such discussions don’t seem to take place, leaving … [Read more…]

Posted in: Acute Pain, Addiction, Buprenorphine, Education, receptor actions, Suboxone, surgery, tolerance Tagged: Buprenorphine, opioid dependence, post-op pain, Suboxone, Suboxone maintenance, surgery, tolerance
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