1. Alex

    A friend of mine starred taking subooxone about a yr ago to get off opiates. She was taking 15 to 20 oxycodone 30s a day.
    She has suffered from migraines since she was 24 and she’s now 41 and her migraines have mutated into cluster headaches and she is in severe pain.
    She started buying roxy 30s about 6 months ago and now she’s taking 4 or 5 roxy’s a day after she takes her 8mg subooxone.
    She says she doesn’t get high off the pain meds that it just helps stop her pain.
    My question is if the sub blocks the opiates and she doesn’t get high from the oxy how cld the oxy help with pain? Isn’t that how narcotics ease pain by giving a euphoric feeling so the person doesn’t feel the pain?
    I guess I’m asking cld the oxy really be helping with her pain or is she just wasting the oxy and sub?

    • I’ll first say that I certainly don’t recommend doing what she is doing without the help of a doctor. Opioids are dangerous medications, and must be used under the direction of a doctor who knows their properties well.
      First though, the euphoric feeling is a side effect of opioid action. Opioids act at the site usually activated by endorphins, and they actually turn off the firing of pain nerve fibers. Some people get euphoria as a side effect; some instead get dysphoria and nausea.
      I have blog posts about combining buprenorphine and agonists (use the search function and search for ‘pain relief without tolerance’ and you will find those posts). When I wrote them I was not aware that others have written about the same combinations a number of years ago. The mechanism for the effect is not clear, but people describe pain relief, without any other subjective effects. Moreover people maintained on the combination long-term do not appear to develop an increase in tolerance.
      I believe that the combination could represent a novel approach to pain treatment. There are naysayers out there who will see the combination from a superficial perspective and say it is a placebo effect, but I know that is not the case, as I’ve used the combination to get patients through some of the most painful operations, including shoulder reconstruction, knee replacement, and chest surgeries.
      Again, anyone on the combination needs to be under the care of a physician.

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