Does Suboxone Stop Working Over Time?

First Posted 12/31/2013
Buprenorphine is relatively unique among opioids in having a ‘ceiling’ to mu opioid effects.  There are other known molecules that act as partial agonists at mu opioid receptors, but buprenorphine is the most useful, at this point, because of other traits of the molecule– such as having few side effects from actions at non-mu receptors.
As most opioid users soon realize, opioid agonists increase tolerance over time to what appears to be an infinite degree.  The mechanisms of tolerance are complicated. I often describe tolerance as a process where receptors become less and less sensitive to opioids with stimulation, to the point where native opioids (endorphins and enkephalins) no longer activate opioid pathways.  Some of the change in sensitivity is caused by the binding of phosphate molecules to the intracellular portion of receptors, causing changes in conformation. Tolerance development is likely far more complicated, though, and includes other changes in synaptic transmission through different mechanisms.

Opioid Effect vs. Dose of Drug
Opioid Effect vs. Dose of Drug

The best model to understand the effects of buprenorphine, in my opinion, is to plot the curve with ‘mu effects’ on the y axis and ‘blood drug level’ or ‘dose’ on the x axis.  Opioid agonists yield a straight line with a slope that correlates with drug potency.  Buprenorphine yields a straight, sloped line in microgram doses and low blood levels, but a horizontal line in high doses.  At a sufficient blood level, buprenorphine essentially sets the tolerance at the degree of opioid effect predicted by that horizontal line.
We could also graph the development of tolerance over time, to high doses of opioids.  Agonists would yield a sloped line that eventually flattens, providing the dose of drug is held constant.  In increase in dose of agonist would cause the line to slope upward for more time, and flatten at a higher level.  With buprenorphine, on the other hand, the slope would flatten at a level that remains constant, even if dose of buprenorphine was increased.
This second graph answers the question of whether buprenorphine or Suboxone stop working at some point in time. From a theoretical standpoint– which is mirrored by clinical experience– tolerance from high-dose buprenorphine does not change beyond the increase in tolerance over the first few weeks of use—- or beyond the decrease in tolerance that was caused by higher amounts of an opioid agonist.  If we graphed the development of tolerance to high dose buprenorphine (say 16 mg per day) vs. time, the graph would be different for opioid-naive persons than for people taking high doses of agonists.  In the former group, the line would slope upward and flatten in days to weeks.  In people taking high doses of opioid agonists, the line would slope steeply downward over the course of minutes, and flatten at the same level as for the first group of patients.  The steep, downward-sloping line would represent the forced-lowering of tolerance by buprenorphine, which is experienced as precipitated withdrawal.  In precipitated withdrawal, buprenorphine is ‘yanking’ tolerance down suddenly.  The graph would be similar for the mu antagonists naltrexone or naloxone, but the point of leveling off would be lower– theoretically at the level of zero, if enough antagonist is used.
I realize that it is difficult to develop mental images from another person’s written descriptions… but I encourage people who want a better understanding of buprenorphine to give the mental images a try.  Once a person can picture the flattening of opioid effect with increased dose or blood level of buprenorphine, the mechanism of action of buprenorphine is easily understood.  As long as the blood level remains above the point where the line becomes horizontal, the opioid effect does not decrease– and so from the brain’s perspective nothing wears off, and nothing ‘comes on’.  Tolerance develops to that level of opioid effect within days to weeks, removing any subjective opioid effect.
After the initial days to weeks on buprenorphine, the tolerance level remains constant– even if the dose of buprenorphine is raised or lowered, as long as the dose remains above the critical level that yields the ceiling effect of the drug.
For those who want ‘just the facts’, the response of opioid receptors to high-dose buprenorphine does not change over time.  Buprenorphine and Suboxone therefore do NOT stop working over time, and there is no need for the dose to change over time.  If anything, my patients tend to move to a lower dose with time, as they find the minimum dose necessary to produce the ceiling effect of buprenorphine throughout the entire dosing interval.
The graphs also explain why there is no truth to the common internet comment that ‘the longer you take buprenorphine, the harder it is to stop’.  Tolerance remains constant, so from a physical standpoint the journey off buprenorphine is the same in three months or three years.  My own clinical experience suggests that people find it progressively easier to stop buprenorphine the longer they take the medication. I have no proof for if or why that occurs, but I suspect that a number of psychological factors are responsible—including the transformation to a new, non-using identity that allows withdrawal symptoms to act aversively and remind people of their desire to stop opioids.
In other words, I suspect that being on buprenorphine for a long time reduces the cravings during withdrawal, instead causing cravings

Why do some docs kick patients off buprenorphine?

I often receive e-mails from people that go something like this:  I was addicted to oxycodone and heroin for 5 years, and lost my marriage, several jobs, and the trust of my children.  I was completely broke, and considering suicide.  Then I heard about treatment with buprenorphine and found a doc who prescribed it.  Since then everything has been going much better; I have a job, I’m putting some savings away, and I have been starting to reconcile with my family.  But my doctor says he wants me off Suboxone and is making me taper, and I’m definitely not ready.  I am starting to panic because I know that if I have to go off buprenorphine I’ll only end up using again.  Is there a way to make him keep me on buprenorphine?

Why the rush off buprenorphine?
Why the rush?

I have described my approach ad nauseum on this blog.  I look at the ‘givens’:
– Despite everyone’s wish that addicts stop using opioids and ‘get off everything,’ it just doesn’t work that way.  The relapse rate after stopping opioids is very high, whether stopping buprenorphine or any other opioid substance.
– Opioid dependence is a chronic illness that never goes away.  People relapse even after years of sobriety.
– Traditional treatment suffers from very high costs and very low success rates, and requires a large time commitment.  Traditional treatment does NOT offer any ‘long term protection’ against relapse; if a person stops attending meetings, the rate of relapse becomes similar to those who never went through treatment.
– Buprenorphine can hold opioid dependence in remission in motivated addicts.  It is not just a ‘substitution’ of one drug for another, as the ‘obsession’ which is the essence of addiction is reduced, allowing personality to improve and for other interests to return.
– The side effects and risks of taking buprenorphine are not significant, especially when compared with treatments for other life-threatening conditions.
– Even a short relapse can have unpredictably severe consequences, including legal trouble, loss of career, loss of key relationships, and death.
I could go on and on with this list, but you get the idea.  My own conclusion then has been that buprenorphine should be considered a long-term treatment for a long-term condition. 
Why do some doctors insist on a short-term approach?  One reason is simple ignorance, and not understanding the nature of opioid addiction.  Many docs persist in seeing addiction as a ‘choice’, and fall into the same silly thinking that some addicts initially believe, that the main barrier to sobriety is withdrawal.  Addicts who become miserable enough to get through withdrawal quickly learn that the withdrawal is NOT the problem—at least not the MAIN problem—as even after the symptoms go away, the addict relapses. This is maddening to the addict’s loved ones, and some doctors see this situation and become angry at the addict, rather than understanding the nature of addiction.  At least there are now studies showing the high rate of relapse, and hopefully the data will change the behavior of physicians prescribing buprenorphine.
Another reason for short-term prescribing is because the buprenorphine is being used as detox, for entry into a ‘total sobriety’ treatment center.  I won’t get too upset about such a situation, except to point out that such treatment centers commonly mislead patients about their chances.  At the treatment center where I used to work, Nova counseling services in Oshkosh, WI, the counselors would get very excited about patients who looked good on their way out the door.  But nobody seemed to feel any responsibility if that same patient relapsed and returned—or died—six months down the line.  Of course many patients never made it to the end of treatment, getting thrown out early or leaving on their own.  The counselors blamed those failures on the patient—instead of recognizing a failing treatment strategy.  THIS IS A VERY SERIOUS PROBLEM, by the way, with residential, traditional treatment programs—a problem that exists because of stigma about addiction, and a sense that addicts are less deserving of good health than ‘normal people.’  How can I say that?  Think of it this way—what if any other illness was managed in this way?  If heart disease or diabetes simply failed to make people better most of the time, and the doctors routinely blamed the patients for the lack of success, how would THAT fly? 
My biggest concern is that there are motivations to get patients off buprenorphine that come from the requirements placed on physicians who prescribe the medication.  Physicians can treat only 30 patients at a time with buprenorphine.  After a year they can apply to raise that limit to 100 patients.  Ironically there is no limit at all on the number of patients a doctor can treat with opioid agonists!  In a typical practice, patients are seen less often as they become more ‘stable’ on buprenorphine, resulting in a situation like mine– I have about 100 patients who have done well on buprenorphine for some time, many of whom had multiple attempts at ‘traditional treatment’ and some who were on buprenorphine from other docs, who would like to stay on buprenorphine long-term.  That’s fine with me; buprenorphine patients are a small part of my practice.  But if I wanted to make significant income from patients on buprenorphine, I would need to clear out spots for new patients who are seen at greater frequency, and who would pay the initial intake fee. 
In other words, doctors are rewarded for high patient turnover, and the growth and earning power of their practices are limited by the cap on the number of patients they can treat.  I understand the reason for the cap; we don’t want to suddenly have thousands of patients on buprenorphine without adequate treatment and supervision.  But there is always a downside to any regulation, and rapid turnover in some practices is a downside to this particular regulation.
I don’t have any particular advice for people who are being forced off buprenorphine for no fault of their own, other than to seek out a new physician.  Patients who are considering starting buprenorphine may want to ask the doctors in their area about their attitudes toward long-term maintenance.   Hopefully over time at least some of the motivations for pushing people off buprenorphine will become less significant.  For the docs who are doing the pushing, I encourage you to examine your own motivations.  I realize that everybody wants to get back to how they were before becoming addicted to opioids… but it is important to remember that nobody can predict the outcome of a relapse, and some people die.

High Dose Buprenorphine (HDB) and Toxicity Concerns

Several weeks ago an article with a provocative title was posted at Suboxone Forum.  I don’t remember the exact title, but it was something like ‘Toxicity from High Dose Buprenorphine (HDB).  Before everyone gets too excited, there was nothing all that new in the article, which consisted of three case reports about deaths of people taking buprenorphine.  One case consisted of a suicide from very large doses of buprenorphine, one was a death from combining buprenorphine with other respiratory depressants, and the third death was in a person with liver failure who took buprenorphine with other psychotropic medications.  There are a couple issues brought up in the article that are worth mentioning.
First, I appreciate their use of the term ‘high dose buprenorphine,’ and this was the first time I came across the distinction between the historical use of buprenorphine in microgram doses for treating pain and the more recent use of milligram doses for treating addiction.   Buprenorphine is an extremely potent opiate; the ceiling effect protects from overdose in the absence of other respiratory depressants (with some exceptions– see below) and places a ‘cap’ on tolerance to the medication, but buprenorphine reaches maximal effect at a very low dose.  The potency of buprenorphine is more similar to that of fentanyl or sufentanil than to morphine or oxycodone.  Transdermal formulations of buprenorphine used for pain release doses of buprenorphine between 5 and 75 MICROgrams per hour.  The most popular dose of buprenorphine used for opiate dependence in the US is the 8 mg Suboxone tablet, which contains 8000 micrograms of buprenorphine!  It is likely that one reason for the occasional death from buprenorphine ingestion relates to fact that a fraction of an 8 mg tablet is about as potent as an entire 8 mg tablet, and novices to buprenorphine make the mistake of thinking that a very small piece will be less likely to kill them than taking an entire tablet.  Because of the ceiling effect and high potency, there is little if any protection in taking a small piece of a tablet.
While the ceiling effect offers some protection against overdose from buprenorphine, there is no protective ceiling effect to the actions of the drug’s primary metabolite, norbuprenorphine.  There have been deaths attributed to the ingestion of very large doses of buprenorphine where the metabolite accumulated to levels that caused respiratory arrest.  It appears that norbuprenorphine does not accumulate to levels sufficient to cause respiratory arrest in people with intact liver function who are taking standard, FDA-approved doses of Suboxone.  But there are a number of medications that inhibit certain liver enzymes, and it is conceivable that the right combination of medications and a large dose of buprenorphine could result in potent respiratory depression.  A number SSRI’s interfere with liver enzymes, the most potent perhaps being fluoxetine or Prozac, but in the case of SSRI’s the enzyme affected converts buprenorphine to norbuprenorphine.  Fluoxetine may in fact then offer a protective effect by preventing conversion of buprenorphine to the more-dangerous metabolite norbuprenorphine.
The respiratory depression potentially caused by norbuprenorphine again draws attention to the fact that very high doses of buprenorphine are used when treating opiate dependence.  We know much about the metabolism and actions of microgram doses of buprenorphine, as the medication has been around for over three decades.  But a number of attributes of the medication change at very high doses.  One very significant change is in the half-life of the medication.  Microgram doses are metabolized in several hours, but at milligram doses the metabolizing enzymes become overwhelmed, increasing the half-life to one to three days.  This increase in half-life is very useful when using buprenorphine to treat opiate dependence… but can be cumbersome when trying to rid the body of buprenorphine, say before elective surgery.
The most frightening question about HDB is whether there are toxic effects from such use that have not been apparent after years of microgram dosing of the medication.  Because of this blog I receive a number of messages from people who take buprenorphine.  I have heard of several cases of neurological illness in people taking buprenorphine, but I have no idea whether the reports represent higher frequencies of illness than would be expected in the general population.  Specifically, I have heard about a person with dementia, a person with encephalopathy, and a relatively young young person who developed symptoms of Parkinson’s Disease.  In all cases, the person was taking buprenorphine for several years.
At this point I must say DON’T HAVE A COW.  To date, several hundred thousand patients have been treated with HDB;  we would expect a number of those people to come down with these conditions in the ABSENCE of any connection between buprenorphine and neurological illnesses.  I continue to prescribe buprenorphine, and I believe WITHOUT RESERVATION that the medication is the best, most appropriate treatment for MOST cases of opiate dependence.  I think it is probably clear to most readers by now that I am not in bed with Reckitt-Benckiser;  I will always write about any concerns that I come across about the medication without delay.  I regularly scan the literature for articles about buprenorphine, and I run literature searches in response to any serious concerns by people in my practice or on the forum.  I also ask that if anyone is aware of a case of neurological illness in a patient who takes buprenorphine, that they contact me so that I can report the information to the FDA.

How Long to Take That Stuff?

I ended the ‘85% off’ sale of the recordings listed to the right of the blog;  they are also listed at the web page ‘Sober After Suboxone,’ along with some other useful recordings about opiate dependence.  I have received good feedback about the recordings, and I think that the ‘how long’ one is the most useful for the people reading this blog;  people at other stages of opiate dependence may find other recordings more useful, such as the one that discusses opiate dependence treatment options.  The treatment options are NOT just a list of the different options available;  they are a list of the options from the perspective of someone (i.e. me) who has dealt with my own opiate addiction for 16 years.  They take into consideration the fact that few people will commit to residential treatment, and more importantly they take into account the relapsing nature of opiate dependence in SPITE of residential treatment options.
The ‘how long are you going to take that stuff’ recording is for the people who are always on your case about Suboxone– the people who think you are still getting high, or the people who say you have ‘substituted one addiction for another’ (you haven’t, by the way).   I take on these and other issues, such as the fantasy about being ‘clean of all substances’ that comes from NA programs from time to time.  I haven’t fully decided on the title of the book I am almost done with, but I like ‘dying to be clean’, as it captures the folly of going off life-sustaining medication to chase after a shame-based goal to be ‘completely clean.’  For parents who keep harping on their children to stop Suboxone, will you feel better when your son or daughter has died from an overdose while trying to avoid the Suboxone that would have kept him or her alive?  DROP THE IDEA OF BEING OFF EVERYTHING.   Opiate dependence is a horribly fatal illness;  if Suboxone is working, count your blessings and appreciate life.  Finally, addiction is not the ‘use’, it is the ‘obsession’.  Suboxone is unique among opiates in that it addresses the obsession.  THAT is what gives you your son or daughter back.
As I said I stopped the 85% off sale, but I did keep a 50% off sale– not actually a sale, but more a permanent 50% price reduction.  I hope you will continue to use the recording, either to arm yourself with knowledge or to share the information with others.
As I have said before, consider the $10 purchase as a donation to the cause.  I really appreciate those of you who have already purchased one or several of the recordings.

Can't Find Long-Term Suboxone Doctor

An e-mail:
I’m stuck in methadone-land, no one will write long term for Suboxone.  I feel trapped and utterly helpless. I’ve been on methadone for a year and a half, and just see no real end in sight.  I am tired all the time, and my friend said that he got on Suboxone and it changed his life.  I’ve been reading about it and trying to find someone in my city to do it but they all only do 90 day detox programs.  What if anything can I do?  I’m out of options short of driving several hours to doctors in other big cities.  I’m in Wichita Ks and the next closest is OKC or KC.
My reply:
I assume you have tried the physician-finder web sites;  in case you haven’t, one is here at, and the other here at  If you haven’t investigated the local practices lately, I encourage you to check them out again;  practices have changed, and more and more docs are realizing that Suboxone is best used long term.  A few years ago 70% of scripts were for detox/short-term;  now 70% are for long-term use.
Consider posting at and maybe someone from your part of the country will have some ideas about docs in your area.

Taking Suboxone Long-Term is Wrong!

I’m sorry, those of you who have been reading this site for the past couple years, to go through this once more…   but I have another of THOSE messages, and it has been, what, a few weeks since I discussed the short-term/long-term issue?   Rest assured that I spare you, the reader, more times than not.  I suppose I could tell the writer of the message (the one I am about to share) that he could search the blog for ‘foolish pharmacist’ or any one of a dozen other posts about the topic and spare me from writing and all of you from reading… but he probably wouldn’t do that.   So in my typical fashion I’ll post his message interspersed with my comments.
The message:
I want to add my perspective on Suboxone. I think it is a great medication but ONLY if used in conjuntion with therapy. It is NOT an anti depressant. It is an OPIATE type medication you are putting into your body with an additional ingredient to block the “high” you get from regular narcotics. The mentality of staying on it “for the rest of your life” is NOT good.
Right off the bat, the writer makes a common mistake– which I’ll get to in a minute.  Of course it isn’t an antidepressant– I would hope that every regular reader of the blog knows that.  Yes, it IS an ‘opiate-type medication’– but so what?  I can assure you that the molecules that have little opiate labels hanging on them are no more evil than any other molecule!  Vivitrol and Revia are ‘opiate-type molecules’ as well– both are trade names for naltrexone, for injection or as a pill, respectively, and both indicated for treatment of alcohol dependence.  There is no logical connection between ‘it is an opiate’ and ‘the mentality of staying on it is NOT good’–  your body doesn’t know ‘opiate’ from ‘indole-amine’ or ‘butyrophenones’ from ‘thioxanthenes’–  they are just names of broad categories of molecules.  Don’t get hung up on labels– they don’t mean anything to the human body.  As for the mistake, the main ingredient in Suboxone is buprenorphine, a chemical that has been used for about 30 years as an analgesic with partial-agonist effects at the mu receptor– as you all know.  People who take Suboxone properly do not get ‘high’, and again, mentioning ‘high’ in the message only confuses the issue.  The added ingredient, by the way, is naloxone– a mu receptor antagonist.  ALL of the effects of Suboxone are due to buprenorphine;  naloxone is added to deter parenteral use of Suboxone.  Naloxone has no important effect for the regular use of Suboxone.
Don’t get me wrong, my partner was put on it last July and it pretty much saved his life as far as I’m concerned. HOWEVER, when the doctor put him on it he said it would help “heal his mind” if used in conjunction with therapy and after 3-4 months would begin to taper him off of it. Well, he went on a business trip and accidently left it behind at one of his stops. He had to be without it for about 5 days and it was hell but as soon as he got it back and resumed he was fine. He shared this with the prescribing doctor who IMMEDIATELY said “Well, you need to be on it longer then since you had such a bad experience being off of it.” There was then NO treatment plan made. Doctors seem to have a sense of vagueness about them when they prescribe this NARCOTIC medication as to what the treatment plan is.
That’s a pretty broad statement about us doctors!  I don’t think that doctors who work with addiction and Suboxone are any more ‘vague’ than other doctors;  I read complaints about doctors of all specialties at the forums I write for at and elsewhere.  I do think that medicine in general has gotten away from the interpersonal relationships that were once a significant part of the doctor-patient bond, but that is a general observation and not specific to addiction treatment.  As regular readers know, I am an opiate addict, and have been for the past 16 years;  I know enough about the mindset of other opiate addicts (I often point out examples of how alike we all are!) to wonder about the communication between your partner and his doctor.  We addicts have very selective hearing, particularly early in the treatment process– so I am reluctant to draw too many conclusions from the ‘he said this’ claims of another opiate addict (like me– did I mention that?).  In other words, I don’t know what the doc said, and to be frank if you weren’t there, you don’t know either.  I doubt that your partner does.  I don’t mean to be insulting;  I’m just telling it like it is, based on working with addicts every day for years, on or off Suboxone.
The reason I am writing this is because what I have observed with longer term use is that my partner was constipated DAILY, slept at least 10 hours per night AND took naps. He did not enjoy excercising as he once did and gained weight. He was mellow and sober but at the same time was not himself. He has been tapering off slowly and is down from 4 mg per day to 2 mg per day. He is not constipated daily any longer, now does fast walks with me every day and passes me up just like the old days. For a while I was out walking him and I hate excercise.
You are attributing all of those things to Suboxone?!  How about your hatred of exercise– what is that from?  Your partner was in the process of trying to stop one of the most addictive substances that there is;  opiate addicts LIVE for using opiates!  For an opiate addict there is but one concern in life– how will I avoid getting sick in four hours?  So here we have your partner– a person who is by all practical sense gravely mentally ill (I could easily argue that the loss of insight and near-delusional obsession to use causes ‘insanity’ as great as in any other psychiatric condition!), and in a span of a few weeks to months has had a dramatic change in his life–  suddenly the crutch that occupied his entire mind has been removed… and you are complaining that he doesn’t like exercising enough?
Today I had a patient who recently started Suboxone and now is having panic attacks.  I explained to him that months ago when he was burglarizing homes and stealing from relatives, he had no worries– because all his mind could think of was using.  Now his mind has been freed from the obsession to use– and all of a sudden he has to think about all of the people he harmed, the consequences that he is facing, etc– so of course he is having anxiety and panic!  Heck, he would be crazy not to!
The writer is blaming Suboxone for the partner’s issues– when the blame should be on his addiction!  It is VERY early, and there are so many things going on those first few months that ‘enjoying exercise’ is a bit silly.   He is trying to recover from a fatal illness, for Pete’s sake.  As for the constipation– I’ll give you that.  That is probably from the Suboxone… but I consider it to be a minor side effect for treatment for a fatal condition–  compared to chemotherapy it’s a great deal.
To sum this up there are no guarantees when it comes to sobriety but to preach horrible relapse statistics to anyone deciding to come off of this NARCOTIC medication is WRONG. Now, if this was something more like a Prozac type medication I would probably better support the “rest of your life” mentality of being on this medication.
I’m not sure how we got from the beginning to your conclusion– you basically say that your partner is addicted to opiates, a horrible condition that destroys and often kills those who suffer from it–  he took Suboxone and it ‘saved his life’… but it made him constipated and he slept too much and didn’t like to exercise– so preaching relapse statistics (correct ones, by the way) is WRONG!.  I don’t get the logic.
The writer is missing the point in a way that is all too common.  The writer blames the ‘rest of your life’ situation on SUBOXONE.  But the truth of the matter is that OPIATE ADDICTION is a life-long condition!    Suboxone isn’t the ‘rest of your life’ issue;  the partner’s opiate addiction is!!
Before Suboxone, opiate addicts like me had a life-long condition that had no good treatments.  Yes, there is NA and AA– they ‘work if you work them’, and I have worked them for a long time.  But twelve-step recovery has ALWAYS been for the very few people who are lucky enough to ‘get it’ before dying from the disease of addiction.  And  people in twelve-step recovery tend to relapse over time, and before Suboxone, relapse was often permanent– many addicts could never get back the sobriety that they once had.  Now we have another option.  But neither Suboxone nor step-work are cures.  And to be frank, there is no ‘therapy’ that cures opiate addiction either.  Yes, therapy is indicated for some patients, but some others do very well without significant therapy.  I do see all patients for at least 30 minutes for every appointment, as there are always things to discuss– but I disagree that EVERY patient on Suboxone needs therapy– just as every patient on meds for bipolar disorder doesn’t need therapy.
If anyone is interested in the issue of Suboxone versus ‘traditional recovery, please read my article on the topic.  Just Google ‘Suboxone’ and ‘traditional recovery’ and you will find it very easily.  To the writer– I’m sorry your partner is an opiate addict.  That is a tough life for anyone.  But Suboxone allows many of my patients the chance to live as if they DIDN’T have a fatal illness.  Many of them tell me that they don’t feel like addicts anymore– they feel like ‘regular people’ with just another illness.  And that is a major paradigm change from traditional treatment and therapy, where the point is to get the addict to identify very strongly with the addict label.   I think there is room for both types of treatment.  In fact, after 16 years of being an opiate addict– it’s about time!!

Long-Term Effects of Suboxone

A note from a reader with a question about Suboxone:

Suboxone has really worked for me in getting off vicodin.But I have been unable to stop taking Suboxone.It occurred to me recently that this may turn into a lifelong dependency.If so, what are the long-term side effects of Suboxone?

Thanks so much,

My Answer:
Suboxone really is best thought of as a long-term, perhaps life-long medication.Your attachment to pain pills will in all likelihood be life-long as well; most people who stop Suboxone are surprised at the cravings for opiates that they have.I don’t think Suboxone increases the cravings at all, but rather it is just so effective at eliminating them that people forget how attached to opiates they once were.I generally recommend that people stay on Suboxone ‘forever’, or until something better comes around– they are much safer on Suboxone, as it helps them avoid an impulsive relapse that can put them in jail, kill them, etc…
We do not know of many long term effects from Suboxone.Long term opiate use in general can lower testosterone levels in men and cause things from that, like reduced sex drive and I suppose even infertility.I assume that buprenorphine will do the same.There are the other short-term side effects that over time become long-term side effects– dry mouth (which long-term can cause an increase in tooth decay), constipation (which could lead to hemorrhoids, diverticulitis, anal fissures or peri-rectal abscess), sweating (which could lead to… problems dating?). The opiate antagonist naltrexone can cause liver damage, and it is related to naloxone, which is a component of Suboxone– in general the naloxone does not get absorbed, and so the chance of liver damage is likely minimal.It may be a good idea to check a set of labs once per year, though, to check the liver, kidneys, thyroid, and blood cell system, just for safety’s sake.
Probably the worst thing about long-term use is that some docs insist upon keeping everyone on Suboxone in endless therapy.I do not think that therapy is generally required, and I do not think that ‘forced therapy’ is very helpful.But it is hard to find a doc who will treat with Suboxone as they would treat with any other treatment for a chronic condition– that is, to prescribe the medication without placing a number of other requirements on the person.
I hope that answers your questions–
Take care,