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opioid tolerance

Tapering off Buprenorphine or Suboxone, Pt 2

August 15, 2018 by admin 10 Comments

In the last post we discussed some of the misconceptions about tapering off opioids.  Today we will discuss a couple basic principles, and then describe the approach I recommend for my patients tapering off buprenorphine. Opioids act at receptors that normally bind endorphins, which are released by neurons in response to a range of stimuli … [Read more…]

Posted in: Addiction, Buprenorphine, pharmacology, receptor actions, Suboxone, Withdrawal Tagged: opioid tolerance, stopping suboxone, suboxone detox, Suboxone taper, tapering off buprenorphine

A New Way to Stop Suboxone?

November 23, 2014 by admin Leave a Comment

Originally Posted 10/27/2013 I usually have my wife/business partner review my posts and provide her opinion whether my arguments are sound.  For the record, she tells me that this post is technical and boring.  I disagree, but we aren’t planning to separate over the issue.  A valid criticism, I think, is that I’m doing a … [Read more…]

Posted in: Buprenorphine, Drug Testing, Mood, Pharma, tolerance Tagged: alks 33, opioid tolerance, samidorphan for depression, stopping suboxone, Suboxone withdrawal

Uncoupling of analgesia, tolerance, and euphoria from mu-agonists using buprenorphine

May 11, 2012 by admin 1 Comment

I presented this topic at the Atlanta meeting of ASAM a couple weeks ago.  There are too many slides, but the historical stuff was just too fascinating to leave out.  I wanted to demonstrate,  by lining it up on the side, how time has compressed the most critical discoveries to a very short period of … [Read more…]

Posted in: Addiction Tagged: Addiction, Buprenorphine, Chronic pain, opioid tolerance, surgery, tolerance, tolerance modulation

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